Increased Vitamin D associated with decreased Cholesterol – Nov 2021

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Association of changes in lipid levels with changes in vitamin D levels in a real-world setting

Scientific Reports volume 11, Article number: 21536 (2021) https://doi.org/10.1038/s41598-021-01064-1
Yonghong Li, Carmen H. Tong, Charles M. Rowland, Jeff Radcliff, Lance A. Bare, Michael J. McPhaul & James J. Devlin

In clinical trials, vitamin D supplementation has been reported to reduce serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) but not high-density lipoprotein cholesterol (HDL-C). In this cohort study we evaluated the association between changes in vitamin D (25-hydroxyvitamin D) and changes in lipid levels in a real-world setting. Changes in lipid levels over a 1-year period were evaluated among individuals whose vitamin D levels increased (group 1) or decreased (group 2) by ≥ 10 ng/mL in year 2018 versus 2017 (cohort 1; n = 5580), in 2019 versus 2018 (cohort 2, n = 6057), or in 2020 versus 2019 (cohort 3, n = 7249). In each cohort, levels of TC, LDL-C, and TG decreased in group 1 and increased in group 2. Between-group differences in average changes in the 3 cohorts ranged from 10.71 to 12.02 mg/dL for TC, from 7.42 to 8.95 mg/dL for LDL-C, and from 21.59 to 28.09 mg/dL for TG. These differences were significant after adjusting for age, sex, race, education, body mass index, blood pressure, smoking status, geographical location, and baseline levels of vitamin D and lipids (P < 0.001). Changes in vitamin D levels were not significantly associated with changes in HDL-C levels.
 Download the PDF from VitaminDWiki

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Note: There appears to be no consensus on the direction of the association

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Cholesterol category starts with the following

52 items below in the VitaminDWiki category = Cholesterol

see also Overview Hypertension and Vitamin D
Search HLD OR LDL   Overview Cardiovascular and vitamin D
Overview Cholesterol and vitamin D

• Less cholesterol in diet resulted in less vitamin D in blood (in mice) – Feb 2016
• Vitamin D levels are (again) associated with HDL cholesterol levels – Feb 2018
• More cholesterol is associated with more vitamin D – June 2013
• Cholesterol, Vitamins D3 and K2, heart disease, sulfates, LDL, – Masterjohn Interview Jan 2013
• Most Profitable Pill in Medical History Is Based on Flawed Science (Statins) May 2019
• Kids have recently reduced both cholesterol and vitamin D – Aug 2012
• Cholesterol is needed to produce both Vitamin D and Cortisol 2011?
• Cholesterol reduced by Vitamin D plus Calcium – RCT March 2014
• Eating less cholesterol is harmless other than it causes vitamin D deficiency – June 2011
• Vitamin D bioavailability is associated with cholesterol – Jan 2011
• Vitamin D increases HDL
• Overview Cholesterol and vitamin D
• Cholesterol and vitamin D book - 2009

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Chart of data by Grassroots Health

Grassroots Health page for the study